Angiotensin II: a candidate for an aldosterone-independent mediator of potassium preservation during volume depletion
نویسندگان
چکیده
منابع مشابه
Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
Wild-type (Agt+/+) and homozygous angiotensinogen deletion mutant (Agt-/-) littermates were placed on normal (NS) or low Na diet (LS) for 2 weeks. Plasma aldosterone levels (P(aldo)) were comparable during NS, and similarly elevated during LS in Agt+/+ and Agt-/-. Moreover, in both, the elevation in P(aldo) was accompanied by marked increase in adrenal zona glomerulosa cells and adrenal P450ald...
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Many studies have implicated both angiotensin II (ANG II) and aldosterone (Aldo) in the pathogenesis of hypertension, the progression of renal injury, and cardiac remodeling after myocardial infarction. In several cases, ANG II and Aldo have been shown to have synergistic interactions in the periphery. In the present studies, we tested the hypothesis that ANG II and Aldo interact centrally in A...
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Impaired renal conservation of sodium (Na) has been reported in potassium (K)-depleted humans and experimental animals when challenged with sodium restriction(l-3); however, the magnitude, duration, or mechanism of this phenomenon have never been clearly defined. It is known that potassium depletion depresses aldosterone secretion and that sodium restriction stimulates it(l,4-7). Johnson et al....
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The role of the renin-angiotensin system in renal hypertension has been investigated for many years but the relationship of the renin-angiotensin system to adrenocortical function has received less attention. In 1951, Deane and Masson,4 using the rat as an experimental animal, reported that encapsulation of the kidney, a procedure which results in hypertension presumably through release of reni...
متن کاملRole of angiotensin II in potassium-mediated stimulation of aldosterone secretion in the dog.
Potassium is known to enhance the aldosterone-stimulating action of angiotensin II. Such a synergistic interaction of potassium with angiotensin II could represent an action by angiotensin II to potentiate potassium as a stimulus. To examine for this effect of angiotensin II on potassium, plasma aldosterone levels were measured before and after an infusion of potassium chloride (15 meq i.v.) in...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2011
ISSN: 0085-2538
DOI: 10.1038/ki.2010.476